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FLASH GENE

Symbol

UXT

contributors: mct - updated : 03-09-2015

HGNC name	ubiquitously-expressed transcript
HGNC id	12641

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Reproductive male system prostate       Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three potential phosphorylation sit

HOMOLOGY

interspecies	homolog to murine Uxt
	homolog to C.elegans H20J04.5

intraspecies

homolog to no

Homologene

FAMILY

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	initially was dispersed in the extranuclear cytosol, then appeared in punctate cytosolic dots, then an intense perinuclear aggregation that eventually invaded and disrupted the nucleus (Moss 2007)

basic FUNCTION	involving in tumorigenesis
	playing a role in facilitating receptor-induced transcriptional activation
	component of centrosome, essential for cell viability and that may facilitate transformation by corrupting regulated centrosome functions
	have cytosolic functions, such as a component of the centrosome and in the transportation of mitochondria
	suppressor of cell transformation, and nuclear factor-KB coregulator
	integral component of the NF-kappaB enhanceosome and is essential for its nuclear function, which uncovers a new mechanism of NF-kappaB regulation
	suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like EVI1
	EZH1 and SUZ12 act as positive regulators for NFKB1 signaling, demonstrating that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms a dynamic complex with NF-kappaB and is recruited to the NF-kappaB enhanceosome upon stimulation

INTERACTION

DNA

RNA

small molecule

protein	with the AR (AF1a and AF1b activation function) increasing the transcriptional activity of AR
	associated with gamma-tubulin
	novel interacting partner of DH/PH domain of ALS2 protein (ALS2 and UXT transcriptional levels are directly correlated through cell cycle)
	UXT is a cofactor of FOXP3 and an important player in Treg-cell function
	EZH1 physically interacts with UXT, a small chaperon-like transcription co-activator

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   contributes to progressive aggregation of mitochondria and cell death potentially through association of UXT with LRPPRC (Moss 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS