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FLASH GENE
Symbol UXT contributors: mct - updated : 03-09-2015
HGNC name ubiquitously-expressed transcript
HGNC id 12641
DNA
TYPE functioning gene
STRUCTURE 7.39 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned   linked   status provisional
regionally located 5' to ELK1, subject to X inactivation
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 797 - 169 - 2012 22131337
  • UXT-V1
  • N-terminal TRAF-binding motif of UXT-V1 binds to the C-terminal TRAF domain of TRAF3, thus facilitating the interaction between TRAF3 and MAVS
  • novel regulator of TNF-induced apoptosis and sheds new light on the underlying molecular mechanism of this process
  • represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction
  • 7 - 619 - 157 ubiquitously expressed 2011 21307340
  • UXT-V2
  • transcriptional cofactor to regulate nuclear factor-KB in the nucleus
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Reproductivemale systemprostate   
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    three potential phosphorylation sit
    HOMOLOGY
    interspecies homolog to murine Uxt
    homolog to C.elegans H20J04.5
    intraspecies homolog to no
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text
  • initially was dispersed in the extranuclear cytosol, then appeared in punctate cytosolic dots, then an intense perinuclear aggregation that eventually invaded and disrupted the nucleus (Moss 2007)
  • basic FUNCTION
  • involving in tumorigenesis
  • playing a role in facilitating receptor-induced transcriptional activation
  • component of centrosome, essential for cell viability and that may facilitate transformation by corrupting regulated centrosome functions
  • have cytosolic functions, such as a component of the centrosome and in the transportation of mitochondria
  • suppressor of cell transformation, and nuclear factor-KB coregulator
  • integral component of the NF-kappaB enhanceosome and is essential for its nuclear function, which uncovers a new mechanism of NF-kappaB regulation
  • suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like EVI1
  • EZH1 and SUZ12 act as positive regulators for NFKB1 signaling, demonstrating that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a dynamic complex with NF-kappaB and is recruited to the NF-kappaB enhanceosome upon stimulation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with the AR (AF1a and AF1b activation function) increasing the transcriptional activity of AR
  • associated with gamma-tubulin
  • novel interacting partner of DH/PH domain of ALS2 protein (ALS2 and UXT transcriptional levels are directly correlated through cell cycle)
  • UXT is a cofactor of FOXP3 and an important player in Treg-cell function
  • EZH1 physically interacts with UXT, a small chaperon-like transcription co-activator
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    contributes to progressive aggregation of mitochondria and cell death potentially through association of UXT with LRPPRC (Moss 2007)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS