basic FUNCTION
| involving in tumorigenesis |
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playing a role in facilitating receptor-induced transcriptional activation |
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component of centrosome, essential for cell viability and that may facilitate transformation by corrupting regulated centrosome functions |
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have cytosolic functions, such as a component of the centrosome and in the transportation of mitochondria |
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suppressor of cell transformation, and nuclear factor-KB coregulator |
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integral component of the NF-kappaB enhanceosome and is essential for its nuclear function, which uncovers a new mechanism of NF-kappaB regulation |
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suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like EVI1 |
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EZH1 and SUZ12 act as positive regulators for NFKB1 signaling, demonstrating that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus |