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FLASH GENE

Symbol

CKAP2

contributors: mct - updated : 13-10-2014

HGNC name	cytoskeleton associated protein 2
HGNC id	1990

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       moderately   liver       highly Lymphoid/Immune lymph node       highly   thymus         Reproductive male system testis     highly   male system prostate     highly Urinary bladder       highly   kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Connective bone     moderately Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Ckap2 (63.1 pc)
	homolog to murine Ckap2 (64.2 pc)

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
text	microtubule-associated protein that localizes to spindle poles
	expression of CKAP2 in the normal human tissues was limited to well-known cell proliferation zones

basic FUNCTION	involved in microtubule stabilization
	involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner
	plays a role in the assembly and maintenance of mitotic spindles, presumably by regulating microtubule dynamics, and its destruction during mitotic exit serves an important role in the completion of cytokinesis and in the maintenance of spindle bipolarity in the next mitosis (Hong 2007)
	mitotic spindle-associated protein which is frequently up-regulated in various malignances
	is essential for proper chromosome segregation and for maintaining genomic stability
	involved in the assembly and maintenance of mitotic spindle and also plays an essential role in maintaining the fidelity of chromosome segregation during mitosis
	plays crucial roles in proper chromosome segregation and maintaining genomic stability
	microtubule-associated protein that localizes to spindle poles and aids in microtubule stabilization
	is involved in the maintenance of microtubule nucleation sites, focusing microtubule minus ends to the spindle poles in early mitosis, and is implicated in maintaining genome stability

CELLULAR PROCESS	cell cycle
	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	associating with alpha- and beta-tubulins
	is a novel substrate of the Aurora B kinase
	SP1 is a major regulator of periodic expression of CKAP2, and cell-cycle-dependent phosphorylation of SP1 mediated by CCNA2 can regulate the DNA-binding affinity of SP1
	RPS6KA1 regulates anchorage-independent growth through transcriptional regulation of factors that modulate cell survival, including ING3, CKAP2, and PTK6

cell & other

REGULATION

Other

cellular functions of CKAP2 might be regulated by timely phosphorylation and dephosphorylation during the course of mitosis

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   resulted in cell cycle arrest during mitosis due to a defect in centrosome separation and subsequent formation of a monopolar spindle (Hong 2007) tumoral     --over   in gastric cancers and large B-cell lymphoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS