Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP1R7 contributors: mct - updated : 24-09-2015
HGNC name protein phosphatase 1, regulatory subunit 7
HGNC id 9295
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunetonsils   highly
Reproductivefemale systemovary  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • showing a tandem array of 11 leucine rich repeat structures (LRR) of 22 residues
  • multiple phosphorylation sites
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast sds 22
    ortholog to murine Ppp1r7
    Homologene
    FAMILY
  • SDS22 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulatory subunit of protein phosphatase 1
  • indirectly and/or directly involved in one of the most ancient functions of PP1, reversing phosphorylation by the Aurora-related protein kinases
  • required for proper progression through mitosis and localization of PP1 to mitotic kinetochores
  • specifically defines PP1 function and localization in mitosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PPP1R7 is kept in solution by formation of a ternary complex with PP1 and PPP1R11
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates PP1 targeting to the kinetochore, accumulation of phospho-aurora B, and force generation at the kinetochore-microtubule interface
  • two PP1-targeting subunits, PPP1R7 and CDCA2, counteracted AURKB-dependent phosphorylation of the outer kinetochore component DSN1 during anaphase
  • TADA3-interacting partners, are AATF (apoptosis-antagonizing transcription factor), and regulatory subunits of the PP1 and PP2A [PPP1R7 and PPP2R5D]
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung, colorectal, gastric, ovarian carcinoma
    tumoral   deletion --low  
    is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS