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FLASH GENE
Symbol PPP1R7 contributors: mct - updated : 24-09-2015
HGNC name protein phosphatase 1, regulatory subunit 7
HGNC id 9295
Location 2q37.3      Physical location : 242.089.901 - 242.122.439
Synonym name
  • protein phosphatase 1 regulatory subunit 22
  • protein phosphatase-1 regulatory subunit 7 alpha2
  • protein phosphatase-1 regulatory subunit 7 beta1
  • protein phosphatase-1 regulatory subunit 7 beta2
  • Synonym symbol(s) SDS22
    DNA
    TYPE functioning gene
    STRUCTURE 34.08 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text with six alternatively spliced variants, SDS22A1 in the brain, SDS22B1, SDS22A2 and SDS22B2
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 2761 41.6 360 - 2010 20921135
    9 splicing 2632 - 317 - 2010 20921135
    10 - 2007 - 344 - 2010 20921135
    9 - 1878 - 301 - 2010 20921135
    8 - 920 - 221 - 2010 20921135
    9 - 1803 - 280 - 2010 20921135
    8 - 1674 27.3 237 - 2010 20921135
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Lymphoid/Immunetonsils   highly
    Reproductivefemale systemovary  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • showing a tandem array of 11 leucine rich repeat structures (LRR) of 22 residues
  • multiple phosphorylation sites
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to yeast sds 22
    ortholog to murine Ppp1r7
    Homologene
    FAMILY
  • SDS22 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulatory subunit of protein phosphatase 1
  • indirectly and/or directly involved in one of the most ancient functions of PP1, reversing phosphorylation by the Aurora-related protein kinases
  • required for proper progression through mitosis and localization of PP1 to mitotic kinetochores
  • specifically defines PP1 function and localization in mitosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PPP1R7 is kept in solution by formation of a ternary complex with PP1 and PPP1R11
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates PP1 targeting to the kinetochore, accumulation of phospho-aurora B, and force generation at the kinetochore-microtubule interface
  • two PP1-targeting subunits, PPP1R7 and CDCA2, counteracted AURKB-dependent phosphorylation of the outer kinetochore component DSN1 during anaphase
  • TADA3-interacting partners, are AATF (apoptosis-antagonizing transcription factor), and regulatory subunits of the PP1 and PP2A [PPP1R7 and PPP2R5D]
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in lung, colorectal, gastric, ovarian carcinoma
    tumoral   deletion --low  
    is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS