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FLASH GENE
Symbol ENTREP3 contributors: mct - updated : 29-08-2023
HGNC name endosomal transmembrane epsin interactor 3
HGNC id 1233
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Nervousbrainhindbraincerebellum  
 nerve   highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • FAM189 family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • FAM189B like NEK1 is required for homologous recombination
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • endogenous NEK1 and FAM189B2 form a tight complex in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hepatocellular carcinoma (HCC) significantly correlated with unfavorable prognosis
    tumoral       gain of function
    in gastric cancer (GC), compared to noncancerous gastric tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • highly expressed ENTRAP3 may serve as an effective prognostic indicator for HCC patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    potential therapeutic target for HCC patients
    ANIMAL & CELL MODELS