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FLASH GENE
Symbol ENTREP3 contributors: mct - updated : 29-08-2023
HGNC name endosomal transmembrane epsin interactor 3
HGNC id 1233
Location 1q22      Physical location : -
Synonym name
  • gene isolated from a human hippocampal library
  • hypothetical protein LOC10712
  • protein COTE1
  • family with sequence similarity 189, member B
  • chromosome 1 open reading frame 2
    • Synonym symbol(s) COTE1, C1orf2, FAM189B
    DNA
    TYPE functioning gene
    STRUCTURE 8.28 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3209 - 668 - 1997 9331372
    9 - 2921 - 572 - 1997 9331372
    11 - 3136 - 650 - 1997 9331372
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousbrainhindbraincerebellum  
     nerve   highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • FAM189 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • FAM189B like NEK1 is required for homologous recombination
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • endogenous NEK1 and FAM189B2 form a tight complex in human cells
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hepatocellular carcinoma (HCC) significantly correlated with unfavorable prognosis
    tumoral       gain of function
    in gastric cancer (GC), compared to noncancerous gastric tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • highly expressed ENTRAP3 may serve as an effective prognostic indicator for HCC patients
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivestomach
    potential therapeutic target for HCC patients
    ANIMAL & CELL MODELS