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FLASH GENE
Symbol SLC29A2 contributors: mct/npt - updated : 17-04-2010
HGNC name solute carrier family 29 (nucleoside transporters), member 2
HGNC id 11004
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestine  highly
endocrinebraindiencephalonpituitary  
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa) highly
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Slc29a2
intraspecies homolog to SLC29A1
Homologene
FAMILY
  • SLC29A transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs
  • nucleobase transporter
  • crucial to maintain physiological plasma levels of adenosine, thus modulating its several biological effects through adenosine receptor activation (Escudero 2008)
  • prominent nucleoside transporters which are responsible for antitumor nucleoside uptake (Endo 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by HIF1A (HIF-1alpha-dependent repression increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine) (Morote-Garcia 2009)
    Other growth factor responsive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS