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FLASH GENE
Symbol SLC29A2 contributors: mct/npt - updated : 17-04-2010
HGNC name solute carrier family 29 (nucleoside transporters), member 2
HGNC id 11004
Location 11q13.2      Physical location : 66.129.992 - 66.139.291
Synonym name
  • equilibrative nucleoside transporter 2 (hydrophobic nuclear protein,36KD)
  • insensitive nucleoside transporter
  • nucleoside transporter, ei-type
  • hydrophobic nucleolar protein, 36 kDa
  • delayed-early response protein 12
  • Synonym symbol(s) HNP36, ENT2, DER12
    DNA
    TYPE functioning gene
    STRUCTURE 9.30 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2529 50 456 - Owen (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestine  highly
    endocrinebraindiencephalonpituitary  
    Lymphoid/Immunethymus   highly
    Reproductivefemale systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa) highly
    Epithelialsecretoryglandularendocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Slc29a2
    intraspecies homolog to SLC29A1
    Homologene
    FAMILY
  • SLC29A transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs
  • nucleobase transporter
  • crucial to maintain physiological plasma levels of adenosine, thus modulating its several biological effects through adenosine receptor activation (Escudero 2008)
  • prominent nucleoside transporters which are responsible for antitumor nucleoside uptake (Endo 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by HIF1A (HIF-1alpha-dependent repression increases mucosal adenosine signaling and attenuates hypoxia-associated inflammation of the intestine) (Morote-Garcia 2009)
    Other growth factor responsive
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in tumor cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS