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FLASH GENE
Symbol LTBR contributors: SGE/npt - updated : 31-05-2010
HGNC name lymphotoxin beta receptor (TNFR superfamily, member 3)
HGNC id 6718
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 stomach   highly
Nervousbrain    
Reproductivemale systemprostate   
Urinarybladder   highly
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
Blood/Hematopoieticleukocyte
Respiratoryalveolar macrophage
cell lineage myeloid lineages but not on T and B cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracytoplasmic cysteine-rich pseudorepeats
  • a small cytoplasmic domain with the serine/threonine kinase but lacking the DEATH domain
  • four TNFR-CYS repeats
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • tumor necrosis factor receptor TNFR superfamily
  • CATEGORY receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 transmembrane protein
    basic FUNCTION
  • specifically binding to the lymphotoxin membrane form and thus playing a role in the development and organization of lymphoid tissues and transformed cells
  • promoting apoptosis via TRAF3 and TRAF5
  • is required for liver regeneration, hepatitis and hepatic lipid metabolism (Tumanov 2007)
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
  • self-associating
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TRAF2 and TNFSF14 (TRAF2, an important effector molecule of TNF signaling, plays a critical, nonredundant role in TNFSF14-LTBR signaling)
  • interacts with HCV core protein
  • receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFSF14
  • interacting with TRAF3, TRAF4, TRAF5
  • ZMYND11 abrogates LTBR function through a protein-protein interaction
  • cell & other
    REGULATION
    Other negatively regulated by TRAF3 (Bista 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • constitutively inducing NF-KappaB activation and it may be associated with autonomous growth of melanoma cells (Dhawan 2008)
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • engagment of Ltbr by Tnfsf14 is essential for both intestinal inflammation and hyperserum IgA syndrome in a murine model that spontaneously develops T cell-mediated intestinal inflammation (Wang 2004)