Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol LTC4S contributors: KTN/npt - updated : 04/11/2008
HGNC name leukotriene C4 synthase
HGNC id 6719
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
 mast cell
Blood/Hematopoieticbasophil
Blood/Hematopoieticeosinophil
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two consensus protein kinase C (PKC) phosphorylation sites
  • three transmembrane domains
  • N-glycosylation site
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to dog LTC4S (91 pc)
    homolog to chimpanzee LTC4S (99.3 pc)
    homolog to cow LTC4S (97 pc)
    homolog to rattus Ltc4s (86 pc)
    homolog to murine Ltc4s (88 pc)
    Homologene
    FAMILY
  • membrane-associated protein in eicosanoid and glutathione metabolism (MAPEG) family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,microsome
    intracellular,nuclear envelope,ext
    text multi-pass membrane protein
    basic FUNCTION
  • catalyzing the first step in the biosynthesis of cysteinyl leukotrienes derived from arachidonic acid
  • catalyzing the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4
  • acting as an enzyme activator
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    leukotriene biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LTC4SD
    Susceptibility to asthma and aspirin-intolerant asthma
    Variant & Polymorphism SNP
  • a -444A/C polymorphism creating an extra recognition site for AP2 enhancer
  • a -1072G/A substitution generating an additional LF-A1 and alpha-INF-2 site
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS