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FLASH GENE
Symbol MPV17L contributors: mct - updated : 03-09-2010
HGNC name MPV17 mitochondrial membrane protein-like
HGNC id 26827
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop (Iida 2006)
    • HOMOLOGY
    interspecies homolog to MPV17
    Homologene
    FAMILY
  • peroxisomal membrane protein PXMP2/4 family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the inner mitochondrial membrane protein Mpv17 (Krick 2008)
  • unique interacting protein and regulator of HTRA2 protease mediating antioxidant and antiapoptotic function in mitochondria (Krick 2008)
  • peroxisomal membrane protein involved in the development of early onset glomerulosclerosis (Iida 2005)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between MPV17L and HTRA2 in mitochondria (Krick 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS