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FLASH GENE
Symbol MPV17L contributors: mct - updated : 03-09-2010
HGNC name MPV17 mitochondrial membrane protein-like
HGNC id 26827
DNA
TYPE functioning gene
STRUCTURE 13.93 kb     4 Exon(s)
regulatory sequence Promoter (CAAT box) (TATA box)
cytosine-phosphate-guanine/HTF
text structure
  • TATA and CCAAT boxes exist 22 to 31 and 64 to 75 bp upstream of exon 1 (Iida 2010)
  • a GC box exists 103 to 116 bp upstream of exon 2
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text M-LPL and M-LPS are generated by the alternative use of two distinct promoters and that the tissue-specific and age-dependent expression of M-LPS is regulated by the promoter located upstream of exon 1 (IIda 2010)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2238 - 147 expressed exclusively in kidneys after the age of 6 weeks Iida (2006), Iida (2010)
  • alsos called MLPH2, MLP-S
  • originally identified as an age-dependently expressed gene, and ZNF205
  • is involved in the age-dependent expression of M-LPS
    4 - 2309 - 196 . localized in peroxisomes . ubiquitous Iida (2006)
  • also called MLPH1, MLP-L
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop (Iida 2006)
  • HOMOLOGY
    interspecies homolog to MPV17
    Homologene
    FAMILY
  • peroxisomal membrane protein PXMP2/4 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the inner mitochondrial membrane protein Mpv17 (Krick 2008)
  • unique interacting protein and regulator of HTRA2 protease mediating antioxidant and antiapoptotic function in mitochondria (Krick 2008)
  • peroxisomal membrane protein involved in the development of early onset glomerulosclerosis (Iida 2005)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between MPV17L and HTRA2 in mitochondria (Krick 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS