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FLASH GENE
Symbol RMI2 contributors: mct/npt - updated : 11-09-2018
HGNC name chromosome 16 open reading frame 75
HGNC id 28349
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth    
 salivary gland    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an OB-fold nucleic acid-binding domain, termed RMI2-OB3 (Xu 2008)
    • HOMOLOGY
    Homologene
    FAMILY
  • RMI2 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • in mitotic cells, BLM and RMI2 were mostly present in the nucleoplasm
    • basic FUNCTION
  • essential for mitotic phosphorylation of BLM (Xu 2008)
  • stimulates the dHJ resolution capability of the BTB complex and isan essential member of the BTB dHJ dissolvasome that is required for the maintenance of a stable genome (Singh 2008)
  • required for chromatin targeting of BLM in response to replication block (Singh 2008)
  • plays critical role in spindle assembly checkpoint (SAC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the BLM complex (Xu 2008)
  • RMI1–RMI2 complex required for BLM complex stability and mitotic phosphorylation of BLM (Xu 2008)
  • BLM forms the BTRR complex with topoisomerase III alpha (TOP3A) and RecQ-mediated genome instability proteins 1 and 2 (RMI1 and RMI2)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RMI1 through two oligonucleotide-binding (OB)-fold domains similar to those in RPA (Xu 2008)
  • interaction with RMI1, and TOP3A for their stability in cells (Singh 2008)
  • RMI2 interacts with the C terminus of RMI1
  • BLM promotes DNA end resection as part of the BLM-TOP3A-RMI1-RMI2 complex
  • TOP3A stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and the processivity of resection is reliant on the TOP3A-RMI1-RMI2 complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BLMLS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS