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FLASH GENE
Symbol RMI2 contributors: mct/npt - updated : 11-09-2018
HGNC name chromosome 16 open reading frame 75
HGNC id 28349
DNA
TYPE functioning gene
STRUCTURE 6.30 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1462 15 147 - 2014 25200081
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouth    
 salivary gland    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an OB-fold nucleic acid-binding domain, termed RMI2-OB3 (Xu 2008)
    • HOMOLOGY
    Homologene
    FAMILY
  • RMI2 family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • in mitotic cells, BLM and RMI2 were mostly present in the nucleoplasm
    • basic FUNCTION
  • essential for mitotic phosphorylation of BLM (Xu 2008)
  • stimulates the dHJ resolution capability of the BTB complex and isan essential member of the BTB dHJ dissolvasome that is required for the maintenance of a stable genome (Singh 2008)
  • required for chromatin targeting of BLM in response to replication block (Singh 2008)
  • plays critical role in spindle assembly checkpoint (SAC)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the BLM complex (Xu 2008)
  • RMI1–RMI2 complex required for BLM complex stability and mitotic phosphorylation of BLM (Xu 2008)
  • BLM forms the BTRR complex with topoisomerase III alpha (TOP3A) and RecQ-mediated genome instability proteins 1 and 2 (RMI1 and RMI2)
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with RMI1 through two oligonucleotide-binding (OB)-fold domains similar to those in RPA (Xu 2008)
  • interaction with RMI1, and TOP3A for their stability in cells (Singh 2008)
  • RMI2 interacts with the C terminus of RMI1
  • BLM promotes DNA end resection as part of the BLM-TOP3A-RMI1-RMI2 complex
  • TOP3A stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and the processivity of resection is reliant on the TOP3A-RMI1-RMI2 complex
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) BLMLS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS