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FLASH GENE

Symbol

ECSIT

contributors: mct - updated : 08-12-2015

HGNC name	ECSIT homolog (Drosophila)
HGNC id	29548

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive stomach       highly Reproductive female system uterus cervix   highly Skin/Tegument skin       highly Visual eye       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

N-terminal targeting signal directing ECSIT to mitochondria, where it interacts with assembly chaperone NDUFAF1 (Vogel 2007)

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus,nucleoplasm

basic FUNCTION	bridges TRAF6 to MAP3K1, and is a regulator of MAP3K1 processing (processing of MAP3K1 is required for its function in the Toll/IL-1 pathway)
	playing an important role in signaling to NF-kappaB
	functions as an essential component in two important signal transduction pathways and playing a role as a cofactor for SMAD proteins in the BMP signaling pathway
	having a function in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development
	cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways (Vogel 2007)
	having a function in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development (Vogel 2007)
	new regulatory role for ECSIT in TLR4 signaling
	multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGFB1, and BMP

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	part of ECSIT complex, including MAP3K7 and TRAF6, playing a pivotal role in TLR4-mediated signals to activate NFKB1
	TMEM126B forms a complex with other assembly factors: NDUFAF1, ACAD9, and ECSIT

INTERACTION

DNA

RNA

small molecule

protein	interacting with chaperone NDUFAF1 in mitochondria and functioning in complex I assembly
	TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway
	TIMMDC1 reciprocally associate with multiple components of the ECSIT-TMEM126B-ACAD9-NDUFAF1 assembly factor complex (MCIA complex), as well as subunits of the soluble and matrix arms
	specifically interacted with RELA/NFKB1 proteins, which colocalized in the nucleus
	ECSIT interacts with TRAF6, is ubiquitinated, and contributes to bactericidal activity during Toll-like receptor (TLR) signaling
	ECSIT interacted with each protein and regulated MAP3K7 activity, leading to the activation of NFKB1

cell & other

REGULATION

Other

ubiquitination of ECSIT might have a role in the regulation of NFKB1 activity in TLR4 signaling

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS