basic FUNCTION
| bridges TRAF6 to MAP3K1, and is a regulator of MAP3K1 processing (processing of MAP3K1 is required for its function in the Toll/IL-1 pathway) |
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playing an important role in signaling to NF-kappaB |
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functions as an essential component in two important signal transduction pathways and playing a role as a cofactor for SMAD proteins in the BMP signaling pathway |
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having a function in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development |
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cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways (Vogel 2007) |
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having a function in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development (Vogel 2007) |
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new regulatory role for ECSIT in TLR4 signaling |
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multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGFB1, and BMP |