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FLASH GENE
Symbol ECSIT contributors: mct - updated : 08-12-2015
HGNC name ECSIT homolog (Drosophila)
HGNC id 29548
Location 19p13.2      Physical location : 11.616.743 - 11.639.987
Genatlas name evolutionarily conserved signaling intermediate in Toll pathways
Synonym name
  • likely ortholog of mouse signaling intermediate in Toll pathway evolutionarily conserved
  • ECSIT protein
  • Synonym symbol(s) SITPEC
    DNA
    TYPE functioning gene
    STRUCTURE 23.26 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1068 - 217 - 1999 10465784
    7 - 1561 - 296 - 1999 10465784
    8 - 1710 - 431 - 1999 10465784
    8 - 1599 - 296 - 1999 10465784
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal targeting signal directing ECSIT to mitochondria, where it interacts with assembly chaperone NDUFAF1 (Vogel 2007)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • bridges TRAF6 to MAP3K1, and is a regulator of MAP3K1 processing (processing of MAP3K1 is required for its function in the Toll/IL-1 pathway)
  • playing an important role in signaling to NF-kappaB
  • functions as an essential component in two important signal transduction pathways and playing a role as a cofactor for SMAD proteins in the BMP signaling pathway
  • having a function in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development
  • cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways (Vogel 2007)
  • having a function in the assembly or stability of mitochondrial complex I, possibly linking assembly of oxidative phosphorylation complexes to inflammatory response and embryonic development (Vogel 2007)
  • new regulatory role for ECSIT in TLR4 signaling
  • multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGFB1, and BMP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • part of ECSIT complex, including MAP3K7 and TRAF6, playing a pivotal role in TLR4-mediated signals to activate NFKB1
  • TMEM126B forms a complex with other assembly factors: NDUFAF1, ACAD9, and ECSIT
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with chaperone NDUFAF1 in mitochondria and functioning in complex I assembly
  • TRIM59, interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway
  • TIMMDC1 reciprocally associate with multiple components of the ECSIT-TMEM126B-ACAD9-NDUFAF1 assembly factor complex (MCIA complex), as well as subunits of the soluble and matrix arms
  • specifically interacted with RELA/NFKB1 proteins, which colocalized in the nucleus
  • ECSIT interacts with TRAF6, is ubiquitinated, and contributes to bactericidal activity during Toll-like receptor (TLR) signaling
  • ECSIT interacted with each protein and regulated MAP3K7 activity, leading to the activation of NFKB1
  • cell & other
    REGULATION
    Other ubiquitination of ECSIT might have a role in the regulation of NFKB1 activity in TLR4 signaling
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS