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FLASH GENE
Symbol USP4 contributors: mct/pgu - updated : 21-02-2012
HGNC name ubiquitin specific peptidase 4 (proto-oncogene)
HGNC id 12627
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestine   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five highly conserved domains, domains I,II and III containing the expected catalytic triad Cys, Asp, His which defines cysteine proteases
  • HOMOLOGY
    interspecies homolog to murine Unp
    Homologene
    FAMILY
  • deubiquitin family
  • peptidase C19 family
  • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text principally expressed in cytosol
    basic FUNCTION
  • functions as a deubiquitinating enzyme
  • modulation of USP4 expression may provide a new means to interfere with canonical Wnt signalling in a variety of physiological and pathological conditions
  • having a role in spliceosome regulation
  • serves as a critical control to downregulate TNF-induced NFKB activation through deubiquitinating MAP3K7
  • deubiquitinase targeting TRAF2 and TRAF6 for deubiquitination
  • negative regulator of TNF- and IL1B-induced cancer cell migration
  • USP4 and USP15 extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • colocalizes with the unubiquitinated form of TRIM21 to the cytoplasmic rod-like structures, where it keeps TRIM21 unubiquitinated
  • deubiquitinating PRPF3
  • interacting with ADORA2A
  • important regulator of TP53
  • interacts directly with and deubiquitinates HUWE1, leading to the stabilization of HUWE1 and subsequent reduction of TP53 levels
  • deubiquitinase for MAP3K7
  • USP4 is an enzyme that removes ubiquitin from PDPK1 in and co-localizes with PDPK1 at the plasma membrane when the two proteins are overexpressed, indicating direct deubiquitination
  • interacts with the PSMD11 subunit of the proteasome via an internal ubiquitin-like (UBL) domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in small cell and adenocarcinoma of lung
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS