Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

CCDC85B

contributors: mct/npt - updated : 03-05-2021

HGNC name	coiled-coil domain containing 85B
HGNC id	24926

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   pancreas exocrine       moderately Reproductive male system prostate     moderately Respiratory lung       predominantly Skin/Tegument skin       moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

two internal coiled-coil domains, believed to participate in DNA transcriptional regulation and no other recognizable domains

HOMOLOGY

interspecies

ortholog to murine Ccdc85b

Homologene

FAMILY

DIPA family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	co-localized with MCRS1 to the nucleus

basic FUNCTION	playing a role in the viral genomic replication of HDV in intact cells by infection with the viral phosphoprotein hepatitis delta antigen (HDAG)
	inhibiting C/EBP beta and -delta proteins
	can act as a repressor of gene transcription, an activity that appears to be enhanced by MCRS1 transcriptional activity and dysfunction of CCD85B may contribute to malignant transformation by affecting the functions of MCRS1
	can act as a repressor of gene transcription, an activity that appears to be enhanced by MCRS1
	CCDC85B constitutes the one of the frameworks of TP53-induced multiple regulatory pathways for beta-catenin activity
	potential roles for the CCDC85A, CCDC85B, CCDC85C and CTNND1 family members in development, motility, and/or adhesion

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	viral phosphoprotein hepatitis delta antigen (HDAG)
	C/EBP beta proteins
	C/EBP-delta proteins
	can associate with MCRS1, a Forkhead-associated domain containing protein implicated in malignant transformation as well as in regulation of gene transcription and translation
	can associate with MCRS1, a Forkhead-associated domain containing protein implicated in malignant transformation as well as in regulation of gene transcription and translation
	regulates beta-catenin activity via interaction with the T-cell factor 4 in the nucleus
	C21orf91 interacts with the coiled-coil domain-containing protein CCDC85B so as to modulate CTNNB1 levels in cells

cell & other

associates with the hepatitis delta antigen

REGULATION

induced by

TP53

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function dysfunction may contribute to malignant transformation by affecting the functions of MCRS1 tumoral     --over   expression of CCDC85B in the cytoplasm of the non-small cell lung cancer (NSCLC) tumor cells was significantly higher compared to adjacent normal lung tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer lung   CCDC85B might serve as a novel target for non-small cell lung cancer treatment

ANIMAL & CELL MODELS