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FLASH GENE
Symbol CCDC85B contributors: mct/npt - updated : 03-05-2021
HGNC name coiled-coil domain containing 85B
HGNC id 24926
Location 11q13.1      Physical location : 65.657.874 - 65.659.105
Synonym name
  • hepatitis delta antigen-interacting protein A
  • delta-interacting protein A
    • Synonym symbol(s) DIPA, FLJ22558, MGC117455
    DNA
    TYPE functioning gene
    STRUCTURE 0.96 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 963 22.1 202 - 2005 15644333
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     pancreas exocrine   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   predominantly
    Skin/Tegumentskin   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two internal coiled-coil domains, believed to participate in DNA transcriptional regulation and no other recognizable domains
    • HOMOLOGY
    interspecies ortholog to murine Ccdc85b
    Homologene
    FAMILY DIPA family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus
    text co-localized with MCRS1 to the nucleus
    basic FUNCTION
  • playing a role in the viral genomic replication of HDV in intact cells by infection with the viral phosphoprotein hepatitis delta antigen (HDAG)
  • inhibiting C/EBP beta and -delta proteins
  • can act as a repressor of gene transcription, an activity that appears to be enhanced by MCRS1 transcriptional activity and dysfunction of CCD85B may contribute to malignant transformation by affecting the functions of MCRS1
  • can act as a repressor of gene transcription, an activity that appears to be enhanced by MCRS1
  • CCDC85B constitutes the one of the frameworks of TP53-induced multiple regulatory pathways for beta-catenin activity
  • potential roles for the CCDC85A, CCDC85B, CCDC85C and CTNND1 family members in development, motility, and/or adhesion
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • viral phosphoprotein hepatitis delta antigen (HDAG)
  • C/EBP beta proteins
  • C/EBP-delta proteins
  • can associate with MCRS1, a Forkhead-associated domain containing protein implicated in malignant transformation as well as in regulation of gene transcription and translation
  • can associate with MCRS1, a Forkhead-associated domain containing protein implicated in malignant transformation as well as in regulation of gene transcription and translation
  • regulates beta-catenin activity via interaction with the T-cell factor 4 in the nucleus
  • C21orf91 interacts with the coiled-coil domain-containing protein CCDC85B so as to modulate CTNNB1 levels in cells
    • cell & other associates with the hepatitis delta antigen
    REGULATION
    induced by TP53
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    dysfunction may contribute to malignant transformation by affecting the functions of MCRS1
    tumoral     --over  
    expression of CCDC85B in the cytoplasm of the non-small cell lung cancer (NSCLC) tumor cells was significantly higher compared to adjacent normal lung tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    CCDC85B might serve as a novel target for non-small cell lung cancer treatment
    ANIMAL & CELL MODELS