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FLASH GENE

Symbol

CYB561D2

contributors: - updated : 29-08-2005

HGNC name	cytochrome b-561 domain containing 2
HGNC id	30253

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   moderately   pancreas exocrine       moderately Lymphoid/Immune lymph node       highly Nervous brain       moderately Reproductive female system ovary     highly Skin/Tegument skin       moderately Urinary bladder       moderately   kidney       predominantly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a cytochrome b561 domain
	six transmembrane helices with both N and C termini in the cytoplasm

HOMOLOGY

interspecies

ortholog to murine Cyb561d2

Homologene

FAMILY

CATEGORY

enzyme , regulatory , transport

SUBCELLULAR LOCALIZATION

basic FUNCTION	acting as an ubiquitin conjugating enzyme
	involved in the regulation of exit from mitosis

CELLULAR PROCESS	cell cycle
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

electron transport

PATHWAY

metabolism

other

signaling

cyclin catabolism

a component

INTERACTION

DNA

RNA

small molecule	other,
	two heme groups noncovalently

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS