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FLASH GENE
Symbol CYB561D2 contributors: - updated : 29-08-2005
HGNC name cytochrome b-561 domain containing 2
HGNC id 30253
DNA
TYPE functioning gene
SPECIAL FEATURE
text
  • residing in a 120-kb critical region for a lung cancer tumor suppressor gene on chromosome 3p21.3
    • STRUCTURE 3.00 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon moderately
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Reproductivefemale systemovary  highly
    Skin/Tegumentskin   moderately
    Urinarybladder   moderately
     kidney   predominantly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytochrome b561 domain
  • six transmembrane helices with both N and C termini in the cytoplasm
    • HOMOLOGY
    interspecies ortholog to murine Cyb561d2
    Homologene
    FAMILY
    CATEGORY enzyme , regulatory , transport
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as an ubiquitin conjugating enzyme
  • involved in the regulation of exit from mitosis
    • CELLULAR PROCESS cell cycle
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism other
    signaling
  • cyclin catabolism
    • a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • two heme groups noncovalently
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS