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FLASH GENE
Symbol KLF17 contributors: mct - updated : 25-09-2013
HGNC name Kruppel-like factor 17
HGNC id 18830
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  predominantly
Endocrinethyroid    
Lymphoid/Immunelymph node    
Nervousbrain    
Reproductivemale systemtestis   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three C2H2-type zinc fingers
  • HOMOLOGY
    interspecies ortholog to murine zinc finger protein 393 (Zfp393)
    Homologene
    FAMILY
  • Sp1 C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may play a role in hematopoiesis
  • can bind G/C-rich sites via its zinc fingers and is able to activate transcription from CACCC-box elements
  • functions to suppress metastasis (Gumireddy 2009)
  • can suppress ID1 transcription (Gumireddy 2009)
  • negative regulator of epithelial-mesenchymal transition (EMT) and metastasis in breast cancer
  • repressing role of KLF17 in tumor invasion in hepatocellular carcinoma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to the CACCC box
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer (Gumireddy 2009)
    tumoral     --low  
    is a valuable prognostic indicator for patients with lung adenocarcinoma, low expression of KLF17 protein was associated with a short survival time in patients with lung adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • combined expression pattern of KLF17 and ID1 can serve as a potential biomarker for lymph node metastasis in breast cancer (Gumireddy 2009)
  • may be a novel biomarker of prognosis in patients with lung adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    could be a novel target for treatment of lung adenocarcinoma
    ANIMAL & CELL MODELS