Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

KLF17

contributors: mct - updated : 25-09-2013

HGNC name	Kruppel-like factor 17
HGNC id	18830

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p34.1      Physical location : 44.584.521 - 44.600.807
Synonym name	zinc finger protein 393
	novel zinc-finger protein
Synonym symbol(s)	Zfp393, FLJ40160, ZNF393

DNA

TYPE	functioning gene
STRUCTURE	16.29 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_173484 4 - 3131 NP_775755 42.4 389 - 2002 1235119

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     predominantly Endocrine thyroid         Lymphoid/Immune lymph node         Nervous brain         Reproductive male system testis

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

three C2H2-type zinc fingers

HOMOLOGY

interspecies

ortholog to murine zinc finger protein 393 (Zfp393)

Homologene

FAMILY

Sp1 C2H2-type zinc-finger protein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	may play a role in hematopoiesis
	can bind G/C-rich sites via its zinc fingers and is able to activate transcription from CACCC-box elements
	functions to suppress metastasis (Gumireddy 2009)
	can suppress ID1 transcription (Gumireddy 2009)
	negative regulator of epithelial-mesenchymal transition (EMT) and metastasis in breast cancer
	repressing role of KLF17 in tumor invasion in hepatocellular carcinoma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to the CACCC box

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in breast cancer (Gumireddy 2009) tumoral     --low   is a valuable prognostic indicator for patients with lung adenocarcinoma, low expression of KLF17 protein was associated with a short survival time in patients with lung adenocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	combined expression pattern of KLF17 and ID1 can serve as a potential biomarker for lymph node metastasis in breast cancer (Gumireddy 2009)
	may be a novel biomarker of prognosis in patients with lung adenocarcinoma
Therapy target
	System Type Disorder Pubmed cancer lung   could be a novel target for treatment of lung adenocarcinoma

ANIMAL & CELL MODELS