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FLASH GENE

Symbol

SAMM50

contributors: mct - updated : 21-11-2017

HGNC name	sorting and assembly machinery component 50 homolog (S. cerevisiae)
HGNC id	24276

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system uterus cervix   highly   female system ovary     highly Skin/Tegument skin       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

many C-terminal membrane-spanning sided beta-sheets having the potential to adopt a transmembrane "beta-barrel" type structure

HOMOLOGY

interspecies	homolog to C. elegans gop-3
	ortholog to murine Samm50

Homologene

FAMILY

SAM50/omp85 family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	may be required for the assembly pathway of mitochondrial outer membrane proteins
	DNM1l is a GTPase protein responsible for mitochondrial division, and SAMM50 is responsible for protein sorting and assembly
	SAMM50 affects the DNM1L-dependent mitochondrial morphology
	tagged SAMM50 is not uniformly distributed in the outer mitochondrial membrane and appears to incompletely overlap with CHCHD3- or IMMT-positive domains, most notably at the crista junctions (CJs)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	SAMM50 is a part of the sorting and assembly machinery (SAM) necessary for the assembly of beta-barrel proteins in the outer membrane (OMM)
	most important subunits of the MIB complex in human mitochondria are IMMT, CHCHD3 and an outer membrane component SAMM50

INTERACTION

DNA

RNA

small molecule

protein	association with six other proteins, metaxins 1, and 2, CHCHD3, CHCHD6 and DNAJC11, IMMT (putative role in protein import related to maintenance of mitochondrial
	MINOS1 interacts with TOMM40 and SAMM50 independently and the core subunit IMMT is involved in biogenesis of outer membrane beta-barrel proteins
	APOOL physically interacts with several subunits of the MINOS complex, namely IMMT, MINOS1, and SAMM50
	IMMT and CHCHD6 directly interacted with SAMM50
	SAMM50 interacts with DNM1L

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS