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FLASH GENE
Symbol SAMM50 contributors: mct - updated : 21-11-2017
HGNC name sorting and assembly machinery component 50 homolog (S. cerevisiae)
HGNC id 24276
Location 22q13.31      Physical location : 44.351.260 - 44.392.411
Synonym name
  • CGI-51 protein
  • sorting and assembly machinery component 50 homolog
  • transformation-related gene 3 protein
    • Synonym symbol(s) SAM50, TRG-3, CGI-51, YNL026W, OMP85, TOB55
    DNA
    TYPE like-sequence
    STRUCTURE 41.15 kb     15 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 1773 - 469 - 2016 27059175
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • many C-terminal membrane-spanning sided beta-sheets having the potential to adopt a transmembrane "beta-barrel" type structure
    • HOMOLOGY
    interspecies homolog to C. elegans gop-3
    ortholog to murine Samm50
    Homologene
    FAMILY SAM50/omp85 family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • may be required for the assembly pathway of mitochondrial outer membrane proteins
  • DNM1l is a GTPase protein responsible for mitochondrial division, and SAMM50 is responsible for protein sorting and assembly
  • SAMM50 affects the DNM1L-dependent mitochondrial morphology
  • tagged SAMM50 is not uniformly distributed in the outer mitochondrial membrane and appears to incompletely overlap with CHCHD3- or IMMT-positive domains, most notably at the crista junctions (CJs)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SAMM50 is a part of the sorting and assembly machinery (SAM) necessary for the assembly of beta-barrel proteins in the outer membrane (OMM)
  • most important subunits of the MIB complex in human mitochondria are IMMT, CHCHD3 and an outer membrane component SAMM50
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • association with six other proteins, metaxins 1, and 2, CHCHD3, CHCHD6 and DNAJC11, IMMT (putative role in protein import related to maintenance of mitochondrial
  • MINOS1 interacts with TOMM40 and SAMM50 independently and the core subunit IMMT is involved in biogenesis of outer membrane beta-barrel proteins
  • APOOL physically interacts with several subunits of the MINOS complex, namely IMMT, MINOS1, and SAMM50
  • IMMT and CHCHD6 directly interacted with SAMM50
  • SAMM50 interacts with DNM1L
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS