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FLASH GENE
Symbol REXO1 contributors: mct - updated : 12-04-2016
HGNC name REX1, RNA exonuclease 1 homolog (S. cerevisiae)
HGNC id 24616
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Endocrineplacenta    
Lymphoid/Immunelymph node    
Reproductivefemale systemovary   
 male systemtestis   
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an exonuclease domain
  • HOMOLOGY
    interspecies homolog to murine Rexo1 (79 pc)
    Homologene
    FAMILY REXO1/REXO3 family
    CATEGORY enzyme , regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as an exonuclease
  • may play some role in the regulation of elongation
  • critically important for efficient transcription elongation of TSIX
  • crucial importance to the RLIM-REXO1 axis in controlling XCI
  • CELLULAR PROCESS nucleotide, transcription, elongation
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RLIM targets REXO1, an inhibitor of X chromosome inactivation (XCI), for proteasomal degradation, regulating initiation of XCI
  • during female embryogenesis, major roles of RLIM have been identified in conjunction with REXO1 during X dosage compensation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS