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FLASH GENE

Symbol

REXO1

contributors: mct - updated : 12-04-2016

HGNC name	REX1, RNA exonuclease 1 homolog (S. cerevisiae)
HGNC id	24616

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.3      Physical location : 1.815.245 - 1.848.452
Synonym name	elongin A binding protein 1
	RNA exonuclease 1 homolog
	transcription elongation factor B polypeptide 3 binding protein 1
Synonym symbol(s)	ELOABP1, KIAA1138, TCEB3BP1, REX1
EC.number	3.1.-.-

DNA

TYPE	functioning gene
STRUCTURE	33.24 kb     16 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020695 16 - 4581 NP_065746 - 1221 - 2003 12943681

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Endocrine placenta         Lymphoid/Immune lymph node         Reproductive female system ovary         male system testis       Urinary bladder

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

an exonuclease domain

HOMOLOGY

interspecies

homolog to murine Rexo1 (79 pc)

Homologene

FAMILY

REXO1/REXO3 family

CATEGORY

enzyme , regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	acting as an exonuclease
	may play some role in the regulation of elongation
	critically important for efficient transcription elongation of TSIX
	crucial importance to the RLIM-REXO1 axis in controlling XCI

CELLULAR PROCESS	nucleotide, transcription, elongation
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	RLIM targets REXO1, an inhibitor of X chromosome inactivation (XCI), for proteasomal degradation, regulating initiation of XCI
	during female embryogenesis, major roles of RLIM have been identified in conjunction with REXO1 during X dosage compensation

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS