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FLASH GENE

Symbol

STON2

contributors: mct/npt - updated : 22-05-2008

HGNC name	stonin 2
HGNC id	30652

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Nervous brain diencephalon hypothalamus     Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal proline-rich domain
	multiple APO-2 interaction motifs
	a stonin homology domain and
	a WVFxF tetrapeptide sequence
	a C-terminal domain homologous to the signal-binding domain of adaptor protein (AP) complex mu subunits

HOMOLOGY

interspecies	ortholog to Caenorhabditis elegans UNC-41B
	homolog to murine Ston2 (89.3pc)

Homologene

FAMILY

stoned B family

CATEGORY

adaptor , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION	component of the endocytic machinery that likely regulates vesicle endocytosis
	may be functioning as an AP-2-dependent sorting adaptor for synaptic vesicle recycling
	may facilitate clathrin-coated vesicle uncoating

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacting indirectly with the AP2 complex and bound to the C2B domains of synaptotagmin-1 and synaptotagmin-2
	interacting with EPS15, EPS15R and ITSN1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS