Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol STON2 contributors: mct/npt - updated : 22-05-2008
HGNC name stonin 2
HGNC id 30652
Location 14q31.1      Physical location : 81.736.910 - 81.864.927
Synonym name
  • stoned B
  • homolog of stoned B
  • stoned B homolog 2 (Drosophila)
    • Synonym symbol(s) STNB, STNB2, STN2
    DNA
    TYPE functioning gene
    STRUCTURE 128.04 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2919 101 905 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Nervousbraindiencephalonhypothalamus  
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal proline-rich domain
  • multiple APO-2 interaction motifs
  • a stonin homology domain and
  • a WVFxF tetrapeptide sequence
  • a C-terminal domain homologous to the signal-binding domain of adaptor protein (AP) complex mu subunits
    • HOMOLOGY
    interspecies ortholog to Caenorhabditis elegans UNC-41B
    homolog to murine Ston2 (89.3pc)
    Homologene
    FAMILY
  • stoned B family
    • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • component of the endocytic machinery that likely regulates vesicle endocytosis
  • may be functioning as an AP-2-dependent sorting adaptor for synaptic vesicle recycling
  • may facilitate clathrin-coated vesicle uncoating
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting indirectly with the AP2 complex and bound to the C2B domains of synaptotagmin-1 and synaptotagmin-2
  • interacting with EPS15, EPS15R and ITSN1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS