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FLASH GENE
Symbol PRRX2 contributors: mct - updated : 22-08-2012
HGNC name paired related homeobox 2
HGNC id 21338
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
Skin/Tegumentskin   lowly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text proliferating fetal fibroblasts, developing dermal layer
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one homeobox domain
  • a regulatory otp, aristaless and rax (OAR) domain
  • HOMOLOGY
    interspecies homolog to murine Prrx2
    Homologene
    FAMILY
  • paired family of homeobox protein
  • aristaless-related homeobox genes family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may have a role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding
  • a role in fetal skin development and a possible role in cellular proliferation
  • PRRX1, and PRRX2, encode transcription factors critical for orofacial development, and are critical for mesenchymal-epithelial signaling during tooth morphogenesis
  • PRRX1 and PRRX2 cooperatively regulate the morphogenesis of the medial region of the mandibular process
  • involvement of PRRX1 and PRRX2 in organogenesis of tissue originating from the ectoderm other than the mesoderm
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice lacking Prrx2 are viable and fertile