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FLASH GENE
Symbol PRRX2 contributors: mct - updated : 22-08-2012
HGNC name paired related homeobox 2
HGNC id 21338
Location 9q34.1      Physical location : 132.427.919 - 132.484.949
Synonym name
  • paired mesoderm homeobox protein 2
  • paired-like homeodomain protein PRX2
  • Synonym symbol(s) PRX2, PMX2, MGC19843
    DNA
    TYPE functioning gene
    STRUCTURE 57.03 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1327 - 253 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung    
    Skin/Tegumentskin   lowly
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text proliferating fetal fibroblasts, developing dermal layer
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one homeobox domain
  • a regulatory otp, aristaless and rax (OAR) domain
  • HOMOLOGY
    interspecies homolog to murine Prrx2
    Homologene
    FAMILY
  • paired family of homeobox protein
  • aristaless-related homeobox genes family
  • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may have a role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding
  • a role in fetal skin development and a possible role in cellular proliferation
  • PRRX1, and PRRX2, encode transcription factors critical for orofacial development, and are critical for mesenchymal-epithelial signaling during tooth morphogenesis
  • PRRX1 and PRRX2 cooperatively regulate the morphogenesis of the medial region of the mandibular process
  • involvement of PRRX1 and PRRX2 in organogenesis of tissue originating from the ectoderm other than the mesoderm
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Mice lacking Prrx2 are viable and fertile