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FLASH GENE
Symbol CCND2 contributors: mct/npt - updated : 27-08-2015
HGNC name cyclin D2
HGNC id 1583
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon highly
Endocrinepancreas   highly Homo sapiens
Hearing/Equilibriumear   highly
Nervousbrainforebraincerebral cortex highly Homo sapiensFetal
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • cyclin family
  • cyclin D subfamily
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • regulator of progression through G1 phase during the cell cycle 2
  • involved in gonadal cell proliferation and oncogenesis
  • playing a crucial role in adipocyte differentiation by regulating mitotic clonal expansion
  • crucial role of CCND2 for the support of cortical intermediate progenitor cells (IPCs) divisions
  • in the basal process of neural progenitors is linked to non-equivalent cell fates
  • role for CCND2 in the postnatal heart as an effector of GATA4 in myocyte growth and survival
  • has a critical role in cell cycle progression and the tumorigenicity of glioblastoma stem cells (GSCs)
  • plays an important role in the induction of early-to-mid G1 phase transition and is required for granulosa cell proliferation during ovarian folliculogenesis
  • positive role of cyclin D2 in Hepatitis B virus (HBV) replication
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • translocates CDKN1B from the nucleus into the cytoplasm for its KPC-dependent degradation at the G(0)-G(1) transition
  • role for CCND2 in the postnatal heart as an effector of GATA4 in myocyte growth and survival
  • SMO signaling, acting through CCND2, is critical for the proper development and maturation of the neocortex
  • is a new ETV4 target gene involved in the control of cellular proliferation and migration, a finding that highlights a new negative regulatory loop between ETV4 and CCND2
  • PTBP1 controls mRNA abundance and alternative splicing of important cell cycle regulators including CCND2, MYC, RBL1 and CDC25B
  • cell & other
    REGULATION
    induced by
  • overexpression of ZKSCAN3 (induced CCND2 promoter activity in a MAF/MAFB-independent manner, and to an extent that was influenced by the number of consensus ZKSCAN3 binding sites)
  • Other FSH acutely regulated CCND2 expression through both PKA and PI3K signaling pathways during granulosa cell proliferation and also accelerated its ubiquitination-proteasomal degradation, which may prevent overstimulation of granulosa cell proliferation and follicular growth
    ASSOCIATED DISORDERS
    corresponding disease(s) MPPH3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytomas and glioblastomas
    tumoral     --low  
    through high methylation levels in invasive prostatic carcinoma, correlating with clinicopathologic features of tumor aggressiveness
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • NAV2 and CCND2 are novel candidate prognostic markers in uterine leiomyosarcoma (LMS) andlow-grade endometrial stromal sarcoma (LG-ESS), respectively
  • Therapy target
    ANIMAL & CELL MODELS