basic FUNCTION
| antagonizing transcriptional activation and cellular transformation by adenovirus E1a |
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contributing to the transcription control of cell growth and differentiation |
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acts as a ligand that enhances differentiation and/or reduces cell proliferation |
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improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling |
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plays a critical role in the inhibition of smooth muscle cells migration |
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novel and potent survival factor for mesenchymal stem cells |
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glycoprotein inhibiting transcription activation, on the regulation of vascular smooth muscle cell apoptosis (VSMCs) |
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plays a key role in modulating VSMC apoptosis through the MAPK14 and JNK signal transduction pathways |
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coexpression of CREG1 and CDKN2A, has a greater effect than either CREG1 and CDKN2A alone to reduce cell growth, induce cell cycle arrest and cellular senescence |
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enhances CDKN2A -induced senescence by transcriptional repression of cell cycle-regulated genes |
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CREG1 is a novel adventitial fibroblasts (AFs) phenotypic modulator in a MAPK14-dependent manner |
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can inhibit NFKB1 activation, TNF-induced inflammatory responses and the hyperpermeability of endothelial cells |
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CREG1 participates in the regulation of apoptosis, inflammation and wound healing of vascular endothelial cells 8) |
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promotes angiogenesis and neovascularization |
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involved in maintaining cellular differentiation and endothelial homeostasis |
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is a conserved lysosomal protein, and an important new factor in regulating tissues homeostasis that has been shown to antagonize injury of tissues or cells |
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CREG1-induced autophagy is required to maintain heart function in the face of stress-induced myocardiac damage |
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protects heart against myocardial ischemia/reperfusion (MI/R) injury-induced cardiomyocytes apoptosis by activating lysosomal autophagy |
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CREG1 plays an important role on the regulation of UCP1 expression and brown adipogenesis |
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essential role for CREG1 in development |