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FLASH GENE
Symbol ABHD12 contributors: mct - updated : 30-08-2014
HGNC name abhydrolase domain containing 12
HGNC id 15868
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
Nervousmicroglia
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • serine esterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • with MGLL, and ABHD6, display distinct subcellular distributions, suggesting that they may control different pools of 2-AG (2-arachidonoylglycerol) in the nervous system
  • membrane-bound enzyme that exhibits monoacylglycerol (MAG) lipase activity
  • performs an essential function in the peripheral and central nervous systems and in the eye
  • could contribute to the metabolism of the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) in the nervous system
  • functions as a major lysophosphatidylserine lipase in the mammalian nervous system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PHARC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Abhd12 -/- mice display massive increases in a rare set of very long chain LPS lipids that have been previously reported as Tlr2 activators