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FLASH GENE

Symbol

ABHD12

contributors: mct - updated : 30-08-2017

HGNC name	abhydrolase domain containing 12
HGNC id	15868

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001042472 13 - 1983 NP_001035937 45.6 398 - 2010 20797687 NM_015600 13 - 1610 NP_056415 45.6 404 - 2010 20797687

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage Nervous microglia

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

serine esterase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	with MGLL, and ABHD6, display distinct subcellular distributions, suggesting that they may control different pools of 2-AG (2-arachidonoylglycerol) in the nervous system
	membrane-bound enzyme that exhibits monoacylglycerol (MAG) lipase activity
	performs an essential function in the peripheral and central nervous systems and in the eye
	could contribute to the metabolism of the endogenous cannabinoid 2-arachidonoylglycerol (2-AG) in the nervous system
	functions as a major lysophosphatidylserine lipase in the mammalian nervous system
	metabolic serine hydrolases ABHD16A and ABHD12 are major lipases that biosynthesize and degrade Lysophosphatidylserine (lyso-PS), respectively in the brain

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

PHARC

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Abhd12 -/- mice display massive increases in a rare set of very long chain LPS lipids that have been previously reported as Tlr2 activators