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FLASH GENE
Symbol MAPK9 contributors: mct - updated : 02-11-2012
HGNC name mitogen-activated protein kinase 9
HGNC id 6886
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   moderately
Endocrinepancreas   highly
Nervousbrain   highly
Reproductivemale systemprostate  moderately
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to C.elegans B0478.1
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in the signal transduction pathway initiated by proinflammatory cytokines and UV radiation
  • playing a necessary role for epithelial morphogenesis and essential regulator of signal transduction by the EGF receptor in the epidermis
  • MAP3K1-MAPK8/9 axis governs the JNK activation levels to control downstream transcriptional events and eyelid morphogenesis and reduction of upstream MAP3K1 signals uncovers analogous but differential roles of MAPK8 and MAPK9 in a biological process
  • both MAPK8 and MAPK9, have cytotoxic potential, however MAPK9 is the primary signal transducer
  • prevents Ras-induced cell senescence and growth arrest by reducing the expression levels of the cell cycle inhibitor CDKN1B and the activation of NF-kappaB
  • role of JNK2 in the mechanism of osmotic stress-induced tight junction disruption in the intestinal epithelium
  • critically involved in stress-induced deficit of contextual fear
  • plays a key role in Ras-induced tumorigenesis
  • critical role for MAPK9 and EPS8 in receptor tyrosine kinase signaling and trafficking to convey distinctly different effects on cell migration
  • enhances growth factor-induced cell migration by regulating RTK trafficking and modulating EPS8 levels
  • MAPK10 mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between MAPK9 and EPS8 may play a role in breast cancer progression
  • WDR62 specifically recruits MAPK8, but not MAPK9, to the spindle pole
  • cell & other
    REGULATION
    activated by threonine and tyrosine phosphorylation
    inhibited by UV light
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in more than 70p100 of human squamous cell carcinoma (SCC) samples
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    represents a promising therapeutic target for cancer
    ANIMAL & CELL MODELS