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FLASH GENE
Symbol MAPK9 contributors: mct - updated : 02-11-2012
HGNC name mitogen-activated protein kinase 9
HGNC id 6886
DNA
TYPE functioning gene
STRUCTURE 58.48 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391859 5 similar to Tb-291 membrane associated protein LOC389351 5 similar to 6-pyruvoyl-tetrahydropterin synthase RUFY1 5q35.3 RUN and FYVE domain containing 1 HNRPH1 5q353 heterogeneous nuclear ribonucleoprotein H1 (H) LOC202404 5q35.3 hypothetical LOC202404 LOC285679 5q35.3 hypothetical protein LOC285679 LOC389352 5 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) CANX 5q35 calnexin MAML1 5q35 mastermind-like 1 (Drosophila) FLJ12121 5q35.3 hypothetical protein FLJ12121 LTC4S 5q35 leukotriene C4 synthase MGAT4B 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130 LOC255426 LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2 KIAA1194 5q35.3 Homo sapiens KIAA1194 (KIAA1194), mRNA. SCGB3A1 5q35-qter secretoglobin, family 3A, member 1 FLT4 5q35.3 fms-related tyrosine kinase 4 LOC134082 5q35.3 similar to seven transmembrane helix receptor LOC134083 5q35.3 similar to Olfactory receptor 2Y1 MGAT1 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase FLJ21458 5q35.3 hypothetical protein FLJ21458 LOC391861 5 similar to cAMP-regulated phosphoprotein 19 (ARPP-19) BTNL3 5q35 butyrophilin-like 3 FLJ32535 5q35.3 butyrophilin 3 FOXO1B 5q35.2-q35.3 forkhead box O1B LOC340050 5q35.3 similar to hypothetical protein LOC340052 5q35.3 similar to seven transmembrane helix receptor LOC285659 5q35.3 similar to Olfactory receptor 2V3
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 splicing 4341 46 382 - 2011 21357683
MAPK9-V1 JNK2A1
12 splicing 4336 - 424 - 2011 21357683
  • MAPK9-V2 JNK2A2
  • differs from other MAPK proteins in two major ways; its autoactivation/autophosphorylation is dependent on dimerization, and dimerization most likely precedes autophosphorylation
  • 12 splicing 4341 46 382 - 2011 21357683
    MAPK9-V3 JNK2B1
    12 splicing 4336 48 424 - 2011 21357683
    MAPK9-V4 JNK2B2
    - - - 46 382 - 2011 21110917
  • contain an intact kinase domain
  • - - - 46 382 - 2011 21110917
  • an intact kinase domain
  • - - - - - - 2011 21110917
  • contains a disrupted kinase domain and it showed a disable function
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveliver   moderately
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  moderately
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to C.elegans B0478.1
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing a role in the signal transduction pathway initiated by proinflammatory cytokines and UV radiation
  • playing a necessary role for epithelial morphogenesis and essential regulator of signal transduction by the EGF receptor in the epidermis
  • MAP3K1-MAPK8/9 axis governs the JNK activation levels to control downstream transcriptional events and eyelid morphogenesis and reduction of upstream MAP3K1 signals uncovers analogous but differential roles of MAPK8 and MAPK9 in a biological process
  • both MAPK8 and MAPK9, have cytotoxic potential, however MAPK9 is the primary signal transducer
  • prevents Ras-induced cell senescence and growth arrest by reducing the expression levels of the cell cycle inhibitor CDKN1B and the activation of NF-kappaB
  • role of JNK2 in the mechanism of osmotic stress-induced tight junction disruption in the intestinal epithelium
  • critically involved in stress-induced deficit of contextual fear
  • plays a key role in Ras-induced tumorigenesis
  • critical role for MAPK9 and EPS8 in receptor tyrosine kinase signaling and trafficking to convey distinctly different effects on cell migration
  • enhances growth factor-induced cell migration by regulating RTK trafficking and modulating EPS8 levels
  • MAPK10 mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interactions between MAPK9 and EPS8 may play a role in breast cancer progression
  • WDR62 specifically recruits MAPK8, but not MAPK9, to the spindle pole
  • cell & other
    REGULATION
    activated by threonine and tyrosine phosphorylation
    inhibited by UV light
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in more than 70p100 of human squamous cell carcinoma (SCC) samples
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    represents a promising therapeutic target for cancer
    ANIMAL & CELL MODELS