| basic FUNCTION
| playing a role in the signal transduction pathway initiated by proinflammatory cytokines and UV radiation |
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playing a necessary role for epithelial morphogenesis and essential regulator of signal transduction by the EGF receptor in the epidermis |
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MAP3K1-MAPK8/9 axis governs the JNK activation levels to control downstream transcriptional events and eyelid morphogenesis and reduction of upstream MAP3K1 signals uncovers analogous but differential roles of MAPK8 and MAPK9 in a biological process |
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both MAPK8 and MAPK9, have cytotoxic potential, however MAPK9 is the primary signal transducer  |
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prevents Ras-induced cell senescence and growth arrest by reducing the expression levels of the cell cycle inhibitor CDKN1B and the activation of NF-kappaB |
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role of JNK2 in the mechanism of osmotic stress-induced tight junction disruption in the intestinal epithelium |
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critically involved in stress-induced deficit of contextual fear |
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plays a key role in Ras-induced tumorigenesis |
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critical role for MAPK9 and EPS8 in receptor tyrosine kinase signaling and trafficking to convey distinctly different effects on cell migration |
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enhances growth factor-induced cell migration by regulating RTK trafficking and modulating EPS8 levels |
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MAPK10 mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm |
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is involved in glioma tumor progression |
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