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FLASH GENE
Symbol MUC5AC contributors: mct - updated : 20-02-2014
HGNC name mucin 5, subtypes A and C, tracheobronchial/gastric
HGNC id 7515
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 stomach    
respiratorylungbronchi   
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivegoblet
Respiratorygoblet cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text gut, stomach
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 24bp tandem repeat domains, interrupted by cysteine-rich subdomains and a putative leucine zipper motif, highly similar to MUC5B
  • nne cysteine-rich domains
  • four proVWF-like D domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • major component of airway mucus involved in intestinal epithelial cell differentiation
  • MUC5AC and MUC5B may play an important role in the pathogenesis of chronic rhinosinusitis and nasal polyposis
  • predominant mucin in the gel phase of sputum in the smoker group
  • may be involved in the pathophysiology of the chronic obstructive pulmonary disease
  • functional immunosuppressive agent, having an important role in pancreatic cancer progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • NRG1 is a novel mediator of MUC5AC and MUC5B expression in bronchial epithelial cells
  • ELANE stimulates the secretion of MUC5AC from airway epithelial cells, and can increase F2RL1 expression and MUC5AC release
  • TRPM5 activation by ATP couples TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via a TLX2 to trigger MUC5AC secretion
  • cell & other
    REGULATION
    inhibited by EGFR inhibitor (enhanced production of MUC5AC was inhibited with an EGFR inhibitor and with a MEK inhibitor, but not with a Src family kinase inhibitor)
    Other regulated by TACE-EGFR cascade
    regulated by a bidirectional circuit between Notch and EGFR signaling pathways
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal neoplasia and in intra-epithelial cancer of the pancreas
    tumoral     --over  
    in the ductal region of human pancreatic cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS