Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

MUC5AC

contributors: mct - updated : 27-11-2024

HGNC name	mucin 5, subtypes A and C, tracheobronchial/gastric
HGNC id	7515

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.5      Physical location : -
Synonym name	apomucin
	gastric mucin
	lewis B blood group antigen
	major airway glycoprotein
	mucin 5, subtypes A and C, tracheobronchial/gastric
Synonym symbol(s)	MUC5, mucin, TBM, leB

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
text	clustered to chromosome 11p15.5 with three other secreted gel-forming mucins, MUC6, MUC2, and MUC5B
STRUCTURE	43.19 kb     49 Exon(s)

MAPPING

cloned

Y

linked

status

confirmed

Map

see MUC6

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MUC5AC - - 41500 146.9 1373 stomach,placenta 2023 37146737 MUC5C - - 3680 115.7 1081 trachea 2023 37146737 NM_001304359 49 - 17448 NP_001291288 - 5654 - 2023 37146737

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       stomach         respiratory lung bronchi       Respiratory respiratory tract trachea

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium     Epithelial barrier/lining uroepithelium

cells

System Cell Pubmed Species Stage Rna symbol Digestive goblet Respiratory goblet cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	gut, stomach

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	24bp tandem repeat domains, interrupted by cysteine-rich subdomains and a putative leucine zipper motif, highly similar to MUC5B
	nne cysteine-rich domains
	four proVWF-like D domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

CATEGORY

secretory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,lumen
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	major component of airway mucus involved in intestinal epithelial cell differentiation
	MUC5AC and MUC5B may play an important role in the pathogenesis of chronic rhinosinusitis and nasal polyposis
	predominant mucin in the gel phase of sputum in the smoker group
	may be involved in the pathophysiology of the chronic obstructive pulmonary disease
	functional immunosuppressive agent, having an important role in pancreatic cancer progression
	MUC5AC is a central effector of allergic inflammation that is required for airway hyperreactivity (AHR) to methacholine
	role of MUC5AC and MUC5B in mucus dysfunction in asthma
	is a molecule with versatile functional implications including barrier functions to epithelial cells, host-pathogen interaction, immune cell attraction to sites of premalignant or malignant lesions and tumor progression in a context-dependent manner
	oxidative stress induces MUC5AC expression through mitochondrial damage-dependent STING1 signaling in human bronchial epithelial cells
	MUC5AC and MUC5B are large glycoproteins that play critical defensive roles in pathogen entrapment and mucociliary clearance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	NRG1 is a novel mediator of MUC5AC and MUC5B expression in bronchial epithelial cells
	ELANE stimulates the secretion of MUC5AC from airway epithelial cells, and can increase F2RL1 expression and MUC5AC release
	TRPM5 activation by ATP couples TRPM5-mediated Na(+) entry to promote Ca(2+) uptake via a TLX2 to trigger MUC5AC secretion
	MUC5AC interacts with ITGB4 that mediates phosphorylation of PTK2 at Y397 leading to lung cancer cell migration
	VEGFA up-regulates MUC5AC expression and RHOA activation by interaction with KDR

cell & other

REGULATION

inhibited by

EGFR inhibitor (enhanced production of MUC5AC was inhibited with an EGFR inhibitor and with a MEK inhibitor, but not with a Src family kinase inhibitor)

Other	regulated by TACE-EGFR cascade
	regulated by a bidirectional circuit between Notch and EGFR signaling pathways

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in colorectal neoplasia and in intra-epithelial cancer of the pancreas tumoral     --over   in the ductal region of human pancreatic cancer tumoral     --over   in benign biliary disease, and biliary tract cancers 2) tumoral     --low   significantly correlated with poor overall survival of gastric cancer patients constitutional       loss of function results in impaired and discoordinated mucociliary transport, respectively, demonstrating the importance of each mucin to airway clearance

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	decreased MUC5AC expression might be a poor prognostic predictor for gastric cancer
	potential diagnostic, prognostic and therapeutic target for various malignancies
	overexpression of MUC5AC is a poor prognostic marker in lung cancer
Therapy target
	System Type Disorder Pubmed cancer     potential therapeutic target for various malignancies respiratory lung   inhibiting MUC5AC may be effective for treating asthma and other lung diseases where it is also overproduced

ANIMAL & CELL MODELS