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FLASH GENE
Symbol IL19 contributors: mct - updated : 09-03-2015
HGNC name interleukin 19
HGNC id 5990
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a signal peptide,two potential N-linked glycosylation sites and four conserved cysteine residues necessary for correct folding of the IL 10 monomer
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to IL10
    Homologene
    FAMILY IL10 family of cytokines
    CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • playing a role in down regulatory antigen presentation and macrophage activation
  • is involved in the pathogenesis of endotoxic shock
  • is an immunomodulatory cytokine, the expression of which is reported to be restricted to inflammatory cells
  • through induction of SOCS5 and inhibition of signal transduction, IL19 expression in VSMCs may represent a novel, protective, autocrine response of VSMCs to inflammatory stimuli
  • is mitogenic and chemotactic for endothelial cell (EC) and can induce the angiogenic potential of ECs
  • involved in keratinocyte proliferation in psoriasis
  • decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability
  • playing a role in B cell activation and autoantibody production
  • has an autocrine effect in breast cancer cells, and directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression
  • the bacterially induced production of IL19 by astrocytes, and the immunomodulatory effects of this cytokine, suggest a novel mechanism by which astrocytes can regulate CNS inflammation
  • IL24 and IL19 are involved in host defence against bacteria and fungi, tissue remodelling and wound healing
  • plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    text anti inflammatory properties
    PATHWAY
    metabolism
    signaling
  • molecular pathway for IL4 up-regulation of IL19 in keratinocytes, which may play an important role in atopic dermatitis (AD) pathogenesis
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • IL19 induced activation of STAT3 as well as the expression of the suppressor of cytokine signaling 5 (SOCS5) in vascular smooth muscle cells (VSMCs)
  • IL19 is important for cutaneous wound healing because it upregulates FGF7 expression
  • cell & other
    REGULATION
    induced by the presence of IL 4 or IL 13 in LPS-treatment stimulated monocytes
    granulocyte-macrophage colony stimulating factor
    LPS-treatmant in monocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to ulcerative colitis (UC)
    Variant & Polymorphism SNP
  • IL19 polymorphisms (rs2243188 and rs2243193) might have a protective role in the development of UC
  • Candidate gene
    Marker
  • is a prognostic marker in breast cancer
  • Therapy target
    ANIMAL & CELL MODELS