basic FUNCTION
| playing a role in down regulatory antigen presentation and macrophage activation |
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is involved in the pathogenesis of endotoxic shock |
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is an immunomodulatory cytokine, the expression of which is reported to be restricted to inflammatory cells |
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through induction of SOCS5 and inhibition of signal transduction, IL19 expression in VSMCs may represent a novel, protective, autocrine response of VSMCs to inflammatory stimuli |
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is mitogenic and chemotactic for endothelial cell (EC) and can induce the angiogenic potential of ECs |
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involved in keratinocyte proliferation in psoriasis |
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decreases leukocyte-endothelial cell interactions by reduction in endothelial cell adhesion molecule mRNA stability |
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playing a role in B cell activation and autoantibody production |
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has an autocrine effect in breast cancer cells, and directly promotes proliferation and migration and indirectly provides a microenvironment for tumor progression |
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the bacterially induced production of IL19 by astrocytes, and the immunomodulatory effects of this cytokine, suggest a novel mechanism by which astrocytes can regulate CNS inflammation |
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IL24 and IL19 are involved in host defence against bacteria and fungi, tissue remodelling and wound healing |
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plays an important role in asthma by stimulating T helper type 2 (Th2) cytokine production |