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FLASH GENE

Symbol

DDX19B

contributors: mct/npt/pgu - updated : 28-07-2009

HGNC name	DEAD (Asp-Glu-Ala-As) box polypeptide 19B
HGNC id	2742

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text

testis

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal region forms an alpha-helical “switch” that negatively regulates ATPase activity
	a DEAD/H box (Asp-Glu-Ala-Asp/His)
	two conserved RecA-like domains that adopt different open structures in the absence of nucleic acid and a closed structure when bound to RNA and ATP
	a C terminal RNA helicase domain

HOMOLOGY

interspecies

ortholog to murine Ddx19b

Homologene

FAMILY	DEAD box helicase family
	DBP5/DDX19 subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nuclear envelope,pore
text	nuclear rims, localized to the cytoplasmic fibrils of the nuclear pore complex
	concentrated and locally activated at the cytoplasmic side of the nuclear pore complex, predominantly cytoplasmic, with a fraction enriched at the nuclear envelope
	present mainly in the cytoplasm and is enriched at the cytoplasmic side of nuclear pore complexes (NPCs), suggesting that it acts in the late part of mRNP export (Zhao 2002)

basic FUNCTION	RNA-dependent ATPase and ATP-dependent RNA-unwinding activities
	essential role for nucleocytoplasmic transport of mRNA-protein (mRNP) complexes
	recruited to the nuclear pore complex and participating in the export of mRNA from the nucleus
	central player in the terminal and directional release of mRNA at the cytoplasmic side of the nuclear envelope
	plays an essential role in the nuclear export of mRNA
	crucial role for mRNA export, and having remodeling activity toward the displacement of the RNA binding protein NAB2
	functions in mRNA export and is thought to remodel mRNPs at the nuclear pore complex (NPC)
	recruited to the cytoplasmic filaments of the nuclear pore complex that is mediated by the nucleoporin NUP214
	enriched at the cytoplasmic face of the nuclear pore complex and may play a critical role in the mRNA-protein complex rearrangement observed on cytoplasmic entry
	playing a role with GLE1 in translation termination
	ATP-dependent RNA binding protein that dissociates from RNA on each hydrolysis event

CELLULAR PROCESS

nucleotide

PHYSIOLOGICAL PROCESS

text	mRNA export from nucleus

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA	binding (N-terminal 90 AAs are involved in regulating DDX19B–RNA binding) (

small molecule	nucleotide,
	ATP

protein	bound to the cytoplasmic nucleoporin NUP214 (NUP214 decreases both the RNA binding and ATPase activities of DDX19B)
	binds to GLE1, components of the cytoplasmic filaments of the nuclear pore complex (GLE1 activate DDX19B ATPase activity and could provide critical spatial regulation of DDX19B activity)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS