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FLASH GENE
Symbol DDX19B contributors: mct/npt/pgu - updated : 28-07-2009
HGNC name DEAD (Asp-Glu-Ala-As) box polypeptide 19B
HGNC id 2742
Location 16q22.1      Physical location : 70.333.071 - 70.367.729
Synonym name
  • DEAD-box protein 5
  • yeast Dbp5 homolog
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)
  • DEAD (Asp-Glu-Ala-As) box polypeptide 19
  • DEAD-box RNA helicase DEAD5
  • ATP-dependent RNA helicase DDX19
  • testicular DEAD-box protein
  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)
    • Synonym symbol(s) DDX19, DBP5, RNAh, tDBP
    EC.number 3.6.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 34.66 kb     12 Exon(s)
    MAPPING cloned Y linked Y status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1831 53 479 - 2002 12219940
    11 - 1738 50 448 - 2002 12219940
  • lacking an in-frame exon in the coding region, as compared to variant 1
  • the resulting isoform 2 lacks an internal segment, as compared to isoform 1
    • 10 - 1728 41 370 - 2002 12219940
  • lacking 2 consecutive exons in the 5' region, as compared to variant 1
  • resulting in translation initiation from a downstream AUG codon and an isoform 3 with a shorter N-terminus compared to isoform 1
    		•
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis  specific
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text testis
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region forms an alpha-helical “switch” that negatively regulates ATPase activity
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • two conserved RecA-like domains that adopt different open structures in the absence of nucleic acid and a closed structure when bound to RNA and ATP
  • a C terminal RNA helicase domain
    • HOMOLOGY
    interspecies ortholog to murine Ddx19b
    Homologene
    FAMILY
  • DEAD box helicase family
  • DBP5/DDX19 subfamily
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nuclear envelope,pore
    text
  • nuclear rims, localized to the cytoplasmic fibrils of the nuclear pore complex
  • concentrated and locally activated at the cytoplasmic side of the nuclear pore complex, predominantly cytoplasmic, with a fraction enriched at the nuclear envelope
  • present mainly in the cytoplasm and is enriched at the cytoplasmic side of nuclear pore complexes (NPCs), suggesting that it acts in the late part of mRNP export (Zhao 2002)
    • basic FUNCTION
  • RNA-dependent ATPase and ATP-dependent RNA-unwinding activities
  • essential role for nucleocytoplasmic transport of mRNA-protein (mRNP) complexes
  • recruited to the nuclear pore complex and participating in the export of mRNA from the nucleus
  • central player in the terminal and directional release of mRNA at the cytoplasmic side of the nuclear envelope
  • plays an essential role in the nuclear export of mRNA
  • crucial role for mRNA export, and having remodeling activity toward the displacement of the RNA binding protein NAB2
  • functions in mRNA export and is thought to remodel mRNPs at the nuclear pore complex (NPC)
  • recruited to the cytoplasmic filaments of the nuclear pore complex that is mediated by the nucleoporin NUP214
  • enriched at the cytoplasmic face of the nuclear pore complex and may play a critical role in the mRNA-protein complex rearrangement observed on cytoplasmic entry
  • playing a role with GLE1 in translation termination
  • ATP-dependent RNA binding protein that dissociates from RNA on each hydrolysis event
    • CELLULAR PROCESS nucleotide
    PHYSIOLOGICAL PROCESS
    text mRNA export from nucleus
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding (N-terminal 90 AAs are involved in regulating DDX19B–RNA binding) (
    small molecule nucleotide,
  • ATP
    • protein
  • bound to the cytoplasmic nucleoporin NUP214 (NUP214 decreases both the RNA binding and ATPase activities of DDX19B)
  • binds to GLE1, components of the cytoplasmic filaments of the nuclear pore complex (GLE1 activate DDX19B ATPase activity and could provide critical spatial regulation of DDX19B activity)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS