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FLASH GENE
Symbol HSD17B6 contributors: npt/ - updated : 29-05-2006
HGNC name hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
HGNC id 23316
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen   lowly
Digestiveliver   highly
Nervousbrainmidbrainsubstantia nigra  
 braindiencephalonamygdala  
 braindiencephalonthalamus  
 brainbasal nucleicaudate nucleus  
 brainlimbic systemhippocampus  
 spinal cord    
Reproductivemale systemprostate  lowly
 male systemtestis  lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Hsd17b9 (73.4pc)
homolog to rattus Hsd17b9 (71.0pc)
intraspecies homolog to RODH4
Homologene
FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • oxidoreductase and epimerase activities
  • involved in androgen catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • NAD+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to polycystic ovary syndrome (PCOS)
    Variant & Polymorphism other polymorphisms in the HSD17B6 gene are associated with PCOS
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS