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FLASH GENE
Symbol HSD17B6 contributors: npt/ - updated : 29-05-2006
HGNC name hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
HGNC id 23316
Location 12q13.3      Physical location : 57.157.107 - 57.181.574
Synonym name
  • hydroxysteroid (17-beta) dehydrogenase 6
  • retinol dehydrogenase
  • oxidative 3 alpha hydroxysteroid dehydrogenase
  • 3(alpha->beta)-hydroxysteroid epimerase
  • short chain dehydrogenase/reductase family 9C, member 6
  • Synonym symbol(s) HSE, RODH, SDR9C6
    EC.number 1.1.1.62, 1.1.1.63, 1.1.1.105
    DNA
    TYPE functioning gene
    STRUCTURE 24.50 kb     5 Exon(s)
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure multiple potential transcription factor binding sites
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1512 35.8 317 - Persson (2009)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
    Digestiveliver   highly
    Nervousbrainmidbrainsubstantia nigra  
     braindiencephalonamygdala  
     braindiencephalonthalamus  
     brainbasal nucleicaudate nucleus  
     brainlimbic systemhippocampus  
     spinal cord    
    Reproductivemale systemprostate  lowly
     male systemtestis  lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Hsd17b9 (73.4pc)
    homolog to rattus Hsd17b9 (71.0pc)
    intraspecies homolog to RODH4
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • oxidoreductase and epimerase activities
  • involved in androgen catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • NAD+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to polycystic ovary syndrome (PCOS)
    Variant & Polymorphism other polymorphisms in the HSD17B6 gene are associated with PCOS
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS