Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PPP1R13B contributors: mct - updated : 13-02-2008
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 13B
HGNC id 14950
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
Endocrinethyroid   highly
Nervousbrain   moderately
Reproductivefemale systemovary  moderately
 male systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal beta-GRASP ubiquitin-like fold suggesting a possible role in binding to other proteins in the apoptotic response network and thus mediating their selective pro-apoptotic functiona proline-rich sequence
  • ankyrin repeats
  • SH3 domain and proline-rich domains
  • HOMOLOGY
    intraspecies homolog to TP53BP2/ASPPZ
    Homologene
    FAMILY
  • ASPP family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • enhancing TP53-induced apoptosis
  • enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic gene
  • regulating the tumor suppression function of TP53
  • having ability to regulate the apoptotic function of TP53 and its family members, TP63 and TP73
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to p53, p63 and p73
  • transcriptional targets of E2F1 (provides another mechanism by which E2F cooperates with TP53 to induce apoptosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type TP53
    tumoral     --low  
    frequently downregulated in in breast carcinomas expressing wild type TP53 (not with mutant TP53)
    tumoral       loss of function
    by aberrant methylation of its promoter in acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    target for cancer therapy
    ANIMAL & CELL MODELS