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FLASH GENE
Symbol SLC30A4 contributors: mct - updated : 16-05-2016
HGNC name solute carrier family 30 (zinc transporter), member 4
HGNC id 11015
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
Reproductivefemale systembreast   
 male systemprostate   
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Lymphoid    
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six putative transmembrane segments, containing a histidine-rich region,(Zn binding) and an aspartic-acid-rich region
  • HOMOLOGY
    interspecies ortholog to murine Znt4
    Homologene
    FAMILY zinc transporter family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    text plasma or organelles membranes
    basic FUNCTION
  • zinc transport out of the cytoplasm
  • with SLC30A4, MAP1LC3A and CASP3 might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component TMEM163 dimerizes with itself but it also heterodimerizes with SLC30A1, SLC30A2, SLC30A3, and SLC30A4 proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MCOLN1 works potentially in concert with SLC30A4 to regulate zinc translocation between the cytoplasm and lysosomes
  • cooperative zinc handling of SLC30A4, metallothionein and SLC30A1 in the cytoplasm is required for full activation of ALPL in the early secretory pathway (ESP), and present clear evidence that the activation process of zinc enzymes is elaborately controlled
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS