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FLASH GENE

Symbol

SLC30A4

contributors: mct - updated : 16-05-2016

HGNC name	solute carrier family 30 (zinc transporter), member 4
HGNC id	11015

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q21.1      Physical location : 45.774.681 - 45.815.002
Synonym name	zinc transporter 4
Synonym symbol(s)	ZNT4

DNA

TYPE	functioning gene
STRUCTURE	40.33 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013309 8 - 4290 - 429 - 2001 11686514

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive female system breast         male system prostate       Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid         Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

six putative transmembrane segments, containing a histidine-rich region,(Zn binding) and an aspartic-acid-rich region

HOMOLOGY

interspecies

ortholog to murine Znt4

Homologene

FAMILY

zinc transporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
	intracellular,cytoplasm,cytosolic,vesicle
text	plasma or organelles membranes

basic FUNCTION	zinc transport out of the cytoplasm
	with SLC30A4, MAP1LC3A and CASP3 might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

TMEM163 dimerizes with itself but it also heterodimerizes with SLC30A1, SLC30A2, SLC30A3, and SLC30A4 proteins

INTERACTION

DNA

RNA

small molecule

protein	MCOLN1 works potentially in concert with SLC30A4 to regulate zinc translocation between the cytoplasm and lysosomes
	cooperative zinc handling of SLC30A4, metallothionein and SLC30A1 in the cytoplasm is required for full activation of ALPL in the early secretory pathway (ESP), and present clear evidence that the activation process of zinc enzymes is elaborately controlled

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS