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FLASH GENE
Symbol CHRNA5 contributors: mct/npt - updated : 28-01-2020
HGNC name cholinergic receptor, nicotinic, alpha 5
HGNC id 1959
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Endocrineneuroendocrinepituitary  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a large N terminal extracellular domain
  • two agonist binding sites
  • four transmembrane (4TM) segments with the M2 domain comprising the cation-selective pore
  • HOMOLOGY
    Homologene
    FAMILY
  • cholinergic receptor family
  • ligand gated ion channel family
  • CATEGORY receptor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • after binding acetylcholine, responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane
  • involved in susceptibility to alcohol dependence (Joslyn 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • composed of two different type of subunits: alpha and non-alpha
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to lung cancer
  • to alcohol and nicotine use disorders
  • to nicotine dependence and lung cancer (Spitz 2008)
  • to chronic obstructive pulmonary disease (COPD)
  • Variant & Polymorphism SNP
  • rs8034191
  • variants were associated with higher risks of lung cancer in lower smoking-exposed strata, and in individuals with a strong family history of lung or smoking-related cancers (Spitz 2008)
  • Candidate gene for low penetrance, high-frequency lung cancer susceptiblity genes
    Marker
    Therapy target
    ANIMAL & CELL MODELS